How much does it cost to open a pharmacy?

An independent pharmacy costs $250,000 to $1.7 million to open. The largest expenses are initial drug inventory ($100,000-$600,000), retail space build-out ($50,000-$300,000), and pharmacy equipment ($30,000-$150,000). Location heavily influences costs since pharmacies need high-traffic retail space with drive-through access in many markets.

Is owning an independent pharmacy profitable?

Independent pharmacies generate average revenue of $3.5 to $5 million annually with net profit margins of 2 to 5 percent on prescriptions and 20 to 40 percent on front-end retail products. Profitability improves with specialty pharmacy services, compounding, immunizations, and clinical services that command higher margins than standard dispensing.

What licenses do you need to open a pharmacy?

You need a state board of pharmacy license, DEA registration for controlled substances, a National Provider Identifier (NPI) number, state business license, and enrollment with insurance networks and PBMs. The pharmacist-in-charge must hold an active pharmacist license. The licensing process takes 3 to 6 months and varies significantly by state.

Pharmacy Startup Cost Comparison

Knoxville, TN vs Chicago, IL

Knoxville, TN

$245,000 - $1,271,000

COL Index: 88.2

Chicago, IL

$323,000 - $1,710,000

COL Index: 107.8

Detailed Cost Comparison

Expense	Knoxville, TN	Chicago, IL	Difference
Licensing & DEA Registration	$5,000 - $20,000	$5,600 - $20,000	-2%
Retail Space & Build-Out	$34,800 - $208,700	$97,800 - $587,000	-64%
Initial Inventory	$100,000 - $600,000	$100,000 - $600,000	Same
Pharmacy Equipment & Technology	$30,000 - $150,000	$30,000 - $150,000	Same
Insurance & Bonding	$8,000 - $25,000	$8,000 - $25,000	Same
Initial Staffing & Training	$17,600 - $70,400	$23,000 - $92,000	-23%
Marketing & Launch	$5,000 - $20,000	$5,000 - $20,000	Same
Working Capital (3 Months)	$44,100 - $176,400	$53,900 - $215,600	-18%
Total Estimated Cost	$245,000 - $1,271,000	$323,000 - $1,710,000	-25%

Local Market Factors

Factor	Knoxville	Chicago
Cost of Living Index	88.2	107.8
Commercial Rent ($/sqft/yr)	$10 - $22	$25 - $65
Labor Rate Index	0.88	1.15
Sales Tax	9.25%	10.25%
Minimum Wage	$7.25/hr	$15.80/hr
LLC Filing Fee	$300	$150

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