How much does it cost to open a pharmacy?

An independent pharmacy costs $250,000 to $1.7 million to open. The largest expenses are initial drug inventory ($100,000-$600,000), retail space build-out ($50,000-$300,000), and pharmacy equipment ($30,000-$150,000). Location heavily influences costs since pharmacies need high-traffic retail space with drive-through access in many markets.

Is owning an independent pharmacy profitable?

Independent pharmacies generate average revenue of $3.5 to $5 million annually with net profit margins of 2 to 5 percent on prescriptions and 20 to 40 percent on front-end retail products. Profitability improves with specialty pharmacy services, compounding, immunizations, and clinical services that command higher margins than standard dispensing.

What licenses do you need to open a pharmacy?

You need a state board of pharmacy license, DEA registration for controlled substances, a National Provider Identifier (NPI) number, state business license, and enrollment with insurance networks and PBMs. The pharmacist-in-charge must hold an active pharmacist license. The licensing process takes 3 to 6 months and varies significantly by state.

Pharmacy Startup Cost Comparison

Portland, OR vs Los Angeles, CA

Portland, OR

$306,000 - $1,604,000

COL Index: 114.7

Los Angeles, CA

$383,000 - $2,006,000

COL Index: 166.5

Detailed Cost Comparison

Expense	Portland, OR	Los Angeles, CA	Difference
Licensing & DEA Registration	$5,000 - $20,000	$5,000 - $20,000	Same
Retail Space & Build-Out	$78,300 - $469,600	$125,000 - $750,000	-37%
Initial Inventory	$100,000 - $600,000	$100,000 - $600,000	Same
Pharmacy Equipment & Technology	$30,000 - $150,000	$30,000 - $150,000	Same
Insurance & Bonding	$8,000 - $25,000	$8,000 - $25,000	Same
Initial Staffing & Training	$22,400 - $89,600	$27,000 - $108,000	-17%
Marketing & Launch	$5,000 - $20,000	$5,000 - $20,000	Same
Working Capital (3 Months)	$57,400 - $229,400	$83,300 - $333,000	-31%
Total Estimated Cost	$306,000 - $1,604,000	$383,000 - $2,006,000	-20%

Local Market Factors

Factor	Portland	Los Angeles
Cost of Living Index	114.7	166.5
Commercial Rent ($/sqft/yr)	$20 - $52	$30 - $85
Labor Rate Index	1.12	1.35
Sales Tax	0%	9.5%
Minimum Wage	$15.95/hr	$16.78/hr
LLC Filing Fee	$100	$70

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